Posted by Larry Hoover on October 11, 2007, at 20:27:04
In reply to Please help w new ? about selegiline prozac combo, posted by Meagan on October 9, 2007, at 10:05:21
> Of course, at higher doses than 10 mg, I've read that selegiline may act on the same MAO (A?) that prozac does; my question is: despite the risk of serotonin syndrome, isn't it possible that having both drugs work on the same MAO will be helpful in my fight against depression?
I'm confused by this comment. Fluoxetine has no MAOI activity that I ever recall hearing about. As you increase the dose of selegeline, there is more inhibition of serotonin breakdown. Maybe that's what you're thinking of, as fluoxetine is a serotonin-reuptake inhibitor.
In my opinion, you've pushed the envelope much further than I ever would consider. On a risk-benefit analyis, your lack of response so far does not justify the increased risk you would take by increasing selegeline dose. I'm glad you're under medical supervision, but I also suggest that you learn all you can about the symptoms of serotonin syndrome. Just because you haven't had it yet doesn't mean you won't develop it, even without increasing anything further.
Lar
poster:Larry Hoover
thread:788058
URL: http://www.dr-bob.org/babble/20071009/msgs/788581.html