Posted by Honore on June 29, 2007, at 0:56:04
In reply to Re: Nothing suggests Vitamin b destroys Nardil » Honore, posted by FredPotter on June 28, 2007, at 23:41:13
Let me argue by inference also:
Vitamin B6 is a treatment for peripheral neuropathy associated with isoniazid, a tuberculous drug also the first MAOI. Isoniazid also causes vitamin B6 deficiency...
(EG:
"It is believed that isoniazid competes with pyridoxyl phosphate for the enzyme apotryptophanase which may lead to symptoms of pyridoxine (vitamin B6) deficiency. Pyridoxine administration can prevent and reverse peripheral neuropathy complicating isoniazid use. Prophylactic pyridoxine administration (e.g., 10 to 50 mg/day) should probably be given routinely in individuals predisposed to develop peripheral neuropathies secondary to isoniazid therapy (e.g., patients who are malnourished, pregnant, alcoholic, diabetic, HIV-infected, or patients receiving higher doses of isoniazid)."
If Vitamin b6 destroyed isoniazid, at least in anything like potentially problematic amounts, so as to render treatment with isozianid ineffective-- it wouldn't be prescribed. Nor would the descriptions of the drugs mention vitamin b6 deficiency caused by isozionid; they would mention that vitamin b6 makes isozianid inactive and therefore not a useful treatment.Thereupon, patients with the effect would have to be given some other drug to treat tuberculosis. Ie, the isoniazid just wouldn't work for them if they needed to take vitamin b6).
Since many sources also suggest that vitamin b6 be prescribed, or used, with phenelzine (nardil), to treat nardil-caused vitamin b6 deficiency, the same would likely be true, don't you think?
Let's assume that the competition for apotryptophanase is two-way, and that therefore some amount of isoniazid, or nardil, might also be rendered ineffective by vitamin b6. It stands to reason, that if treatment with vitamin b6 for the peripheral neuropathy or vitamin b6 deficiency caused by nardil were going to negate the effects of nardil, nardil would simply have to be withdrawn from those who showed symptoms of vitamin b6 deficiency. Plus, I would expect that to be noted in the regular PDR as a contraindication for nardil-- or as a problematic condition in its use.
There's nothing of that sort at all anywhere that I can find, including the PDR.
So, I'm going to assume that since vitamin b6 is a recommended treatment for vitamin b6 deficiency in patients using nardil, that the nardil remains effective in the presence of vitamin b6.
Nothing else stands to reason.
So, I honestly think that taking vitamin v6 with nardil is well within reason, although not necessarily required. (Not everyone who takes nardil will have vitamin b6 deficiency, although it is well-known to exist.)
Does that in any way convince you of at least the great unlikelihood that any danger or threat to nardil exists in taking vitamin b6 with it; and that, moreover, much good may very possibly be done?
Honore
poster:Honore
thread:765488
URL: http://www.dr-bob.org/babble/20070622/msgs/766615.html