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Re: Ironically, POSITIVE of the fatigue has been . » malcolm64

Posted by Quintal on May 1, 2007, at 19:24:30

In reply to Re: Ironically, POSITIVE of the fatigue has been ., posted by malcolm64 on May 1, 2007, at 18:33:47

Although Parnate and Nardil are both MAOIs they are different drugs with different effects. MAOIs in general tend to have an activating, stimulant effect which often increases nervous tension. Think EMSAM, selegiline, moclobemide etc.

Nardil is unique in boosting GABA, and therefore being anxiolytic and calming. There are some studies re: Nardil's effect on GABA and its metabolite phenylethylidenehydrazine here http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=pubmed_DocSum&db=pubmed&cmd=Display&dopt=pubmed_pubmed&from_uid=11754874. This is probably where the similarities to drunkenness come from - many people here have said the same thing.

I'm not sure how your pdoc is judging the power of each MAOI. Parnate is certainly a powerful drug, but probably less effective *for anxiety* as a monotherapy than Nardil for the reasons I've already explained. There's more info on the differences between Parnate and Nardil here: http://www.psychotropical.com/maois_full.shtml. This doesn't mean Parnate isn't effective for anxiety, especially in combo with a benzo, but taken as a monotherapy it has quite a different feel to Nardil.

Q


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