Posted by Larry Hoover on April 13, 2007, at 9:28:44
In reply to Is phenylethylamine neurotoxic?, posted by falconman on April 13, 2007, at 7:53:12
> Does the fact that we break this chemical down so quickly signify that its maybe toxic?
No. Not that I know of.
> Could it be an evolutionary self-protection mechanism that serves an important purpose?
More of a signal control mechanism. Cells communicate, but the idea is to limit the time course of the signal, so that there is a real-time responsivity within the system. Quick degradation "cleans up the mess".
> If you take low dose deprenyl(selegeline) and DL-phenylalanine together, to increase production and reduce its break down; could you possibly be playing with fire?
> ThanksThe only fire aspect would be that changes in receptor function might occur, as an adaptive mechanism. For many functions where we try to play around with natural processes by manipulating e.g. precursors, we find that the initial responsivity dampens over time. That's because Mama Nature has feedback regulatory systems embedded all over the place, is all.
To maintain overt physiological response over time, it's probably best to go with p.r.n. dosing of the phenylalanine, in this example. Take it as needed, and try to avoid changes in the responsivity of the system. You do not want it to learn to accommodate the exogenous source, but to remain "hungry" for the signal you seek. Holidays from exposure serve a similar function. You can only learn how this works for you by experimentation.
Lar
poster:Larry Hoover
thread:749466
URL: http://www.dr-bob.org/babble/20070413/msgs/749477.html