Posted by laima on February 27, 2007, at 14:29:07
In reply to Re: Drug manufacturing and quality control, posted by notfred on February 27, 2007, at 13:45:28
Well, gosh, I can personally say it hasn't helped that I've been feeling so defensive and invalidated by umpteen pharmacists and pharmacy techs-that one being so bold as to say she was going to give me generic and over-ride the doctor's instructions even- so maybe if I read your post more carefully and without emotional investment the nature of the content would have been more obvious to me. Sorry about a misunderstanding. Thanks for all of your info.
> Ah ! Sorry I did not pick up on this & that it was not clear I was agreeing with you.
>
> For many drugs you cannot just take the raw drug and expect it to be well/evenly absorbed. Often times raw drugs cannot be made into pills as the raw drug will not bind to itself, so binders and fillers are needed to form a pill that will hold its shape. Other additives make sure the med is released at the right place in your GI and/or is released smoothly. With the wrong additives it is possible to pass a pill through your GI without it ever breaking up.
>
> Brands have to prove bioavalibility, generics do not prove that their bioavalibility is equal to the brand. Standards like USP make sure generic prozac is the same chemical as brand prozac but it is a totally different issue as to how well the generic prozac is taken up by your body vs. the brand.
poster:laima
thread:735309
URL: http://www.dr-bob.org/babble/20070224/msgs/736817.html