Posted by Quintal on December 17, 2006, at 9:03:24
In reply to Re: Do APs block the euphoric effects of opiates?, posted by Vale on December 17, 2006, at 7:02:42
>There is a definite "neuroleptic flavour" ( for want of a better definition) about them, even at low dose.And they are prescibed throughout the dose range for negative/positive symptoms of schizophrenia.
>I'm curious about the 'neuroleptic flavour' you talk about. Amisulpride felt nothing like any other AP I've taken - it felt very similar to the other dopamine agonists to me. It made me feel light and energetic - even euphoric at the beginning. I seemed much more alert and mentally sharp. The negative side effects I normally associate across the spectrum of APs are heavy sedation, mental slowing/cognitive impairment, vacant facial expression/zoning out etc, anhedonia/dysphoria, akathisia/restlessness, parkinsonism, dystonia and other EPS. None of these were a problem for me with amisulpride in doses of 50mg and below, and I didn't notice any problems at 150mg either - it just seemed to lose its energising effect.
I know the boyfriend of my friend who has schizophrenia was unwisely prescribed amisulpride with flupentixol to overcome the dysthymia he was having and they caused a severe manic episode. He had not had this problem with flupentixol alone even though it is known to provoke mania in susceptible people. This suggests to me that amisulpride does have quite a different flavour to the other neuroleptics which usually suppress mania.
>In order to achieve more consistency I combine it with a low dose 25mg of Hydroxycin ( Atarax) a Piperazine, not too far removed from the classic neuroleptics. This has the effect of A/ potentiation of the Opiate euphoric effects. B/ Prolongation of those effects
>Hydroxyzine is not an antipsychotic and can't be compared to them for this purpose. Some antipsychotics are piperazine derivatives but piperazine derivatives vary as widely as Viagra, pesticides and cattle wormers which are clearly not antipsychotics. The piperazines, particularly BZD, MCPP and TFMPP are being used in 'Pep Pills' here in the UK (and are rapidly being outlawed) as they are powerful stimulants and are marketed as legal harm-reduction amphetamine and ecstasy alternatives.
I've heard of people using antihistamines to enhance to opiate high. I sometimes use diphenhydramine (Nytol One-a-night/Benadryl) for this purpose and to reduce the itching. Atarax is not often used here and can be hard to obtain. I once asked my GP for some as a non-benzodiazepine anxiolytic and she refused because the BNF discourages it for some reason.
Q
poster:Quintal
thread:713536
URL: http://www.dr-bob.org/babble/20061217/msgs/714511.html