Posted by psychobot5000 on December 15, 2006, at 21:30:04
In reply to Re: Risperdals MOA+some Dopamine boosters MOA » psychobot5000, posted by Paulbwell on December 15, 2006, at 0:56:22
> Interesting that Risperdal blocks DA2 receptors, along with NE-alpha receptors, which in low AD doses (.25-1mg) shouldn't be TOO noticable, but raise the dose to AP levels, and it'll make thoes Stims struggle.
>
> I wonder what AP and stim, you used and the doses?Those are some interesting/useful profiles you posted--very nice. As for my AP/stimulant combinations, I was on Seroquel 50mg (a low dose), and took either dexamphetamine 5-10mg (I'm fairly sensitive), or Concerta 18mg or 27mg, depending on the day. So the doses of all of them are fairly low, but I didn't feel like their effects had a very complicated interaction. Felt like just one on top of the other, though in some ways the antipsychotics seemed flattening in a way that was that contrasted with the stims. Nevertheless, the stimulants, when taken, would have their normal psychological effects...just starting out from a different baseline mental state, so the end result was different, but not blocked as far as I could tell. Make sense? Anyway, that was my experience, though it's a little hard to judge it precisely. APs feel kinda weird.
P-bot
>
> -RISPERDAL:
>
> risperidone Risperdal, Risperidal, Belivon, Risperin, Rispolept, Rispolin antipsychotic, depression AP: 4-16mg
>
> AD: 0.5mg-2mg RM: 3 hrs
> SM: 20 hrs
> CYP-3A
> P-gp * benzisoxazole:
> neuroleptic
> DA2 antagonist ++
> 5-HT2a antagonist +++
> NE-alpha antagonist ++
> H1 antagonist +
>
> -DEXEDRINE:
>
> dextroamphetamine
> (d-amphetamine) Dexedrine, DextroStat ADD, ADHD, narcolepsy, obesity 5-30mg
> (40mg max) 10-25 hrs
> CYP-2D6 * psychostimulant:
> NE release +++
> DA release ++
> DA reuptake inhibition +
> NE reuptake inhibition +
>
>
> -RITALIN:
>
> methylphenidate Ritalin, Concerta, Metadate, Methylin, Methylphen ADD, ADHD, depression, CFS 20-30mg
> (60mg max) 2.9 hrs * psychostimulant:
> DA reuptake inhibition
> NE reuptake inhibition
> NE release
>
> -ADDERALL:
>
> amphetamine
> (mixed salts) Adderall, Biphetamine ADD, ADHD, narcolepsy, depression, AD sexual side-effects 5-40mg
> (60mg max) 10-25 hrs
> CYP-2D6 * psychostimulant:
> NE release +++
> DA release ++
> DA reuptake inhibition +
> NE reuptake inhibition +
>
> -DESOXYN:
>
> methamphetamine Desoxyn, Methampex, Methedrine, Pervitin, Temmler ADD, ADHD, obesity 10-25mg 10-25 hrs
> CYP-2D6 * psychostimulant:
> 5-HT release +++
> NE release +++
> DA release ++
> DA reuptake inhibition
> NE reuptake inhibition
>
poster:psychobot5000
thread:712252
URL: http://www.dr-bob.org/babble/20061212/msgs/714095.html