Posted by linkadge on September 14, 2006, at 11:39:36
In reply to Re: Glutamatergic neurotransmission and mood disor, posted by SLS on September 14, 2006, at 9:00:40
Another thing to consider is this. Persons with a family history of unipolar depression often show atrophy in the prefrontal cortex. So even under the most ideal conditions, the frontal cortex might be in a state of hypofunction. In this case, you've got certain drugs that can boost activity there. While they are not curing the atrophy, they may restore some ballance that may not be otherwise achievable.
So perhaps the hippocampus is hypfunctioning as a result of prefrontal hypofunction. In which case directly targeting the hippocampus may
not completely restore normal behavior.
Linkadge
poster:linkadge
thread:685302
URL: http://www.dr-bob.org/babble/20060909/msgs/685891.html