Posted by linkadge on September 8, 2006, at 7:21:26
In reply to Re: Remeron not sexual SE free., posted by johnnyj on September 7, 2006, at 21:19:56
>Can you explain that a little more? alpha-2 >antagonist? Is this a seratonin receptor?
Remeron works by blocking a certain receptor called the norpinephrine alpha-2 autoreceptor.
These receptors work by putting the breaks on norepinephrine release. So, by blocking this receptor, the brain releases more norepinephrine.Nortryptaline has a noradrenergic mechanism too, though slightly different. It prevents the reuptake of norepinehprine allowing more of it to stay in the synapse.
Agents like these two (which work on norepinephrine) can cause irritability. Norepinephrine is a fight-or-flight hormone which can heighten agression, and edgyness.
Neither of these agents has had testing for application to OCD. The SSRI's however have. Roughtly speaking, norepinephrine is an excitory neurotransmitter wherase serotonin is inhibitory. There have been case reports of Remeron worsening OCD possably due to its ability to increase frontal cortex dopaminergic output.
>I am really, really hoping that luvox, if I go >for it, will be sedating instead of activating >for me. I guess the only way is to try it.Some people find luvox sedating while other find it slightly activating. It should not be nearly as activating as say Nortryptaline. Start with a low dose to see how it may affect you. Trazodone would be a good augmenting agent should insomnia occur.
Celexa or Lexapro too, may be slightly more tollerable than luvox. They are slightly newer SSRI's.
>OH MY GOD, I have never heard that but I always >felt that I would get "stuck" on something and >couldn't get it out of my mind. I would replay >things over and over and find myself saying the >same word over and over in my mind. I never did >it to that extent before. Very scary.For me, Remeron made the same song play over and over again in my head.
>You are very kind linkadge. What is your dx and >meds if you do not mind me asking. I hope you >are well.
My diagnosis was major depression, but I have taken several meds in the past but am currently on no meds. I may need to return to meds somewhere down the road.
Linkadge
poster:linkadge
thread:683074
URL: http://www.dr-bob.org/babble/20060901/msgs/684192.html