Posted by jedi on June 21, 2006, at 0:17:36
In reply to Re: At what point are meds justified (social anxie, posted by mike lynch on June 20, 2006, at 16:35:31
> When it comes to meds aside from anti-depressants such as clonzepan, does this med, or are there meds where the emotional numbing, amotivational side effects aren't present. I think the absolute best med would be one that works on dopomaine, that way you'd get the exact opposite of amotivation and emotional numbing while solving your anxiety problems.
Hi Mike,
There is some evidence that dysregulation of the dopaminergic system can play an important role in social anxiety. I haven't used it but maybe modafinil(Provigil) along with a small dose of clonazepam(1mg) would work. Does anyone have any experience or thoughts on this?
Be Well,
JediNeurobiological Mechanisms of Social Anxiety Disorder
Abstract:
OBJECTIVE: The authors critically surveyed several preclinical and clinical neurobiological models of social anxiety disorder. METHOD: The authors reviewed the recent literature regarding three animal models of particular relevance to social anxiety. They then examined the recent literature concerning clinical neurobiological aspects of social anxiety disorder, including the developmental neurobiology of anxiety, the genetics of fear and social anxiety, and challenge and imaging studies. RESULTS: The available animal models are useful paradigms for understanding the features of social subordination stress, attachment behavior, and environmental rearing, but they incompletely account for the known neurobiology of human social anxiety disorder. The clinical neurobiology literature surveyed implicates specific neurotransmitter system abnormalities, most notably of the dopamine system, but largely ignores neurodevelopmental processes and the functional interactions between neurotransmitters. Both heritable factors and environmental stress factors appear to be responsible for the onset of social anxiety disorder. CONCLUSIONS: Social anxiety disorder should be conceptualized as a chronic neurodevelopmental illness that might represent a fully compensated state in adulthood. Future investigations from this perspective are discussed.
Full Article:
http://ajp.psychiatryonline.org/cgi/content/full/158/10/1558#F1Low Dopamine D2 Receptor Binding Potential in Social Phobia
Abstract:
OBJECTIVE: This study compared dopamine D2 receptor binding potential in patients with social phobia and healthy comparison subjects. METHOD: Dopamine D2 receptor binding potential was assessed in 10 unmedicated subjects with generalized social phobia and no significant lifetime psychiatric comorbidity and 10 healthy comparison subjects matched for age and sex. Binding potential was measured in the striatum by using single photon emission computerized tomography and constant infusion of the D2 receptor radiotracer [123I]iodobenzamide ([123I]IBZM). RESULTS: Mean D2 receptor binding potential was significantly lower in the subjects with social phobia than in the comparison subjects. Within the social phobia group, there was a nonsignificant correlation of binding potential with the Liebowitz Social Anxiety Scale score. CONCLUSIONS: Generalized social phobia may be associated with low binding of [123I]IBZM to D2 receptors in the striatum.
Full Report:
http://ajp.psychiatryonline.org/cgi/content/full/157/3/457?ijkey=3e69e0b77dbdf8ea9f8f30788d90052dc24833afPotential Uses of Modafinil in Psychiatric Disorders
Full Article:
http://jrnlappliedresearch.com/articles/Vol4Iss2/Bransfield-Jar-spring.pdf
poster:jedi
thread:659095
URL: http://www.dr-bob.org/babble/20060617/msgs/659561.html