Posted by linkadge on June 20, 2006, at 17:13:25
In reply to Re: Opiates, posted by flmm on June 19, 2006, at 19:51:26
Nobody here is suggesting that the euphoric feeling that opiates give at first is the antidepressant response.
Some people actually feel euphoric on an antidepressant for the first little while, yet they can still continue to gain a theraputic effect once the euphoria has worn off.
Take Nardil for instance. Many people notice that during the first month's usage, they feel euphoric. Though, even after this wares off many people continue to gain a theraputic effect against depression.
Sure, there are going to be those who will continue to chase after that euphoric feeling (not mentioning any names).
Some doctors are actually uncomfortable with the fact that MAOI's can often produce this initial effect, and won't prescribe them based on this.
What we are trying to do here, is to find out if a person can take an opiate (beyond the timeframe to end euphoria) and still gain a theraputic effect at a constant dose.
It seems that a growing number of patients claim this is the case. Are these patients junkies? If so, why would they remain satisfied at a fixed dose ?
Sure the opiate receptors will adjust to the increased opiate agonism and downregulate, but so too will serotonin receptors in the presence of SSRI's.
Who was it who posted a study not too long ago that said that morphine was equal to imipramine for treating melancholic depression at fixed doses, and relapse occured upon withdrawl of either agent.
Linkadge
poster:linkadge
thread:651514
URL: http://www.dr-bob.org/babble/20060617/msgs/659347.html