Posted by notfred on June 11, 2006, at 21:08:36
In reply to Re: EMSAM doses too low to effect depression ?, posted by Jakeman on June 11, 2006, at 20:10:34
> I don't know if EMSAM inhibits MAO-A. Perhaps at the higher doses? Maybe some of our MAOI experts can chime in. According to their studies it has efficacy for major depression even at the lowest dose.
>
> warm regards, JakeYes, that is fundamental and well known as to why there are no dietary restrictions at lower doses. EMSAM does not inhibit MAO-A at lower doses. This alone and not its transdermal delivery system accounts for the lack of dietary restrictions.
By 1968, further research had shown that there were two types of MAO-A and B. It is primarily intestinal MAO-A that digests incoming tyramine. Most of the MAO inhibitors that have been used clinically inhibit both MAO-A and MAO-B, thus setting up the danger of the cheese effect by inhibiting intestinal and brain MAO-A, allowing “toxic” tyramine levels to accumulate. Deprenyl is unique among clinically used MAO-Is. At normally used clinical dosages (10-15 mg/day), deprenyl is a selective MAO-B inhibitor, so it doesn’t prevent intestinal MAO-A from digesting dietary tyramine. (1) In addition, deprenyl has the unique ability to prevent tyramine from getting into noradrenalin-using nerve calls, and it’s only when tyramine enters noradrenalin nerve cells that control arterial blood pressure that it triggers the “cheese effect.” (1) Deprenyl thus has a dual “safety lock” in preventing the “cheese effect,” making it far safer than other MAO inhibitors. At doses over 20-30 mg/day, however, deprenyl does start to significantly inhibit MAO-A , so there is some risk of the “cheese effect” at these higher (rarely clinically used) doses. (1)
poster:notfred
thread:655515
URL: http://www.dr-bob.org/babble/20060610/msgs/655711.html