Posted by Larry Hoover on May 16, 2006, at 10:13:50
In reply to Re: I need help....insomnia, posted by Guy on May 14, 2006, at 12:38:01
> Larry, with the support fo your doctor, you could try dumping the tricyclics and substituting 5 - 10 mg of Zyprexa.
I've been thinking about my apparent paradoxical reaction to Seroquel, in the context of the H1 receptor activity. When I tried Seroquel, and found myself unable to sleep, I was greatly surprised. My pdoc virtually dismissed me. Like I wasn't telling him the truth.
I wonder, though, if it wasn't because I was doing a drug substitution, rather than a straight forward drug trial. I took Seroquel instead of the Restoril (temazepam), and I was alert the whole night.
So, I'm wondering if the two agents don't bind to different parts of the receptor. I presume that nobody knows that for sure. But, really, I was doing two changes, changing two variables, and attributing all of the outcome to just one of the drugs. I don't think that I took Seroquel with temazepam. It was long enough ago that I don't remember. I'm almost certain I substituted meds, one for the other. I'm almost certain that's what my pdoc told me to do.
Is the combination contra-indicated in any way? Is it safe to take an atypical (Zyprexa or Seroquel) with the benzo, and then begin a taper?
Any opinions out there?
Lar
poster:Larry Hoover
thread:643862
URL: http://www.dr-bob.org/babble/20060515/msgs/644683.html