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Re: Statistical question on SSRIs - ADDENDUM » SLS

Posted by Larry Hoover on May 15, 2006, at 14:53:05

In reply to Re: Statistical question on SSRIs - ADDENDUM, posted by SLS on May 15, 2006, at 12:54:42

> It must be difficult to tease out from existing data the statistical rate at which an antidepressant drug induces a suicidal state that is not an artefact of an improvement in the depressive state produced by that drug. Some percentage of suicides are the result of a drug performing the task we ask it to.
>
>
> - Scott

Precisely.

Yet, the sum of the (hypothetically) induced, and the natural incidence, is what we now observe. The upper bound of the induced, must be, perforce, the total observed incidence of all suicides. But, that limiting case would itself require that the natural incidence has gone to zero. So, the worst case scenario for induction would also be the best case scenario for overall efficacy.

Lar

 

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poster:Larry Hoover thread:640557
URL: http://www.dr-bob.org/babble/20060515/msgs/644327.html