Posted by linkadge on April 30, 2006, at 17:29:53
The study below compared the effects on swimming of mice lacking either SERT, NET or DAT.
Interestingly, the SERT knockout mice displayed the *least* mobility (ie little antidepressant effect), the NET knockout mice lasted a little longer, but the DAT knockout mice were the least depressed of the bunch.
I think DAT inhibitors would make well for antidepressants, but we'll never see them cause they might be abused.
http://www.ibnshomepage.org/FullAbstract.asp?ID=131
Linkadge
poster:linkadge
thread:638491
URL: http://www.dr-bob.org/babble/20060429/msgs/638491.html