Posted by zeugma on April 20, 2006, at 18:49:59
In reply to Re: Drugs versus Psychotherapy - Backlash?, posted by linkadge on April 20, 2006, at 17:55:02
Another argument is that we have drugs such as straterra, which are NRI's but display only weak, negligable effect in depression.
One would think that if the if NET inhibition was the key mechanism, then any drug which inhibited it would be an antidepressnat.>>
I don't know the answer to this. In the case of Strattera, I have supposed that since Strattera's metabolite is a kappa opiod partial agonist, a depressogenic effect counteracts its NRI-based antidepressant effect.
Even reboxetine is not a pure NRI: it blocks nicotinic ACh receptors. Reboxetine seems to be an effective antidepressant from numerous studies, and yet it doesn't seem to work for anybody who posts here. Maybe everyone who has taken reboxetine and gotten a positive result is so deliriously happy that they have no need to post here.
-z
poster:zeugma
thread:629584
URL: http://www.dr-bob.org/babble/20060417/msgs/635367.html