Posted by linkadge on April 16, 2006, at 12:40:44
In reply to Re: Nardil Euphoria MalcolmS » linkadge, posted by MARTY on April 15, 2006, at 21:59:50
Hmm, I know that anticholinergics are sometimes used to lessen the withdrawl from antidepressants.
A lot of antidepressants are functional anticholinergics. There is a serotoninergic/cholinergic axis, noradrenergic/cholinergic axis, dopaminergic/cholinergic axis.
So when you increase the monoamines, you are suppressing cholinergic function in certain ways. Discontinuation often involves a rebound in the cholinergic function, which can cause all sorts of reactions, so you may be able to reduce withdrawl by using an anticholinergic.
That is one take on it. I know anticholinergics are used to reduce TCA withdrawl.
The TCA's can do a double whammy on supressing cholinergic function. The molecules themselves are anticholinergics, but when combined with increase in noradrenaline, I would assume the axis gets a strong shift. That is one theory about depression is that it is an imballence in the choliergic/adrenergic axis, and that drugs can try and pull it more in the favor of noradrenergic dominance.
Linkadge
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URL: http://www.dr-bob.org/babble/20060412/msgs/633836.html