Re: topamax and wellbutrin XL

Posted by JaclinHyde on April 1, 2006, at 15:28:12

In reply to topamax and wellbutrin XL, posted by challenged on March 30, 2006, at 3:12:41

Here is what I have learned about combining Wellbutrin and Geodon. I even checked Abilify and Wellbutrin with the same result.
"Patient Regimen
GEODON ORAL
WELLBUTRIN ORAL
Interactions
Moderate Interaction
BUPROPION/ANTIPSYCHOTICS
Wellbutrin Oral and Geodon Oral may interact based on the potential interaction between BUPROPION and ANTIPSYCHOTICS.
Bupropion/Antipsychotics
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
MONOGRAPH TITLE: Bupropion/Antipsychotics
SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed.
MECHANISM OF ACTION: Both bupropion and the antipsychotics are known to lower the seizure threshold.(1)
CLINICAL EFFECTS: Concurrent use of bupropion and an antipsychotic may result in additive effects on the seizure threshold, increasing the risk of seizures.(1)
PREDISPOSING FACTORS: The risk of seizures may be increased in patients with a history of head trauma or prior seizure; CNS tumor; severe hepatic cirrhosis; excessive use of alcohol or sedatives; addiction to opiates, cocaine, or stimulants; use of over-the-counter stimulants an anorectics; a total daily dose of bupropion greater than 450 mg or single doses greater than 150 mg; rapid escalation of bupropion dosage; diabetics treated with oral hypoglycemics or insulin; or with concomitant medications known to lower seizure threshold (antidepressants, theophylline, systemic steroids). (1)
PATIENT MANAGEMENT: The concurrent use of bupropion and antipsychotics should be undertaken only with extreme caution and with low initial bupropion dosing and small gradual dosage increases.(1)
DISCUSSION: Because of the risk of seizure from concurrent bupropion and other agents that lower seizure threshold, the manufacturer of bupropion states that the concurrent use of bupropion and antipsychotics should be undertaken only with extreme caution and with low initial bupropion dosing and small gradual dosage increases.(1)
REFERENCE:
1.Wellbutrin (bupropion hydrochloride) US prescribing information. GlaxoSmithKline January, 2005."
Hope this helps!
JH

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topamax and wellbutrin XL challenged 3/30/06
Re: topamax and wellbutrin XL JaclinHyde 4/1/06

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