Posted by SLS on March 23, 2006, at 20:40:26
In reply to Re: SSRI's indirectly influence DAT (negatively ?), posted by SLS on March 23, 2006, at 20:37:55
On second thought, never mind. Dumb idea.
> > http://www.nature.com/cgi-taf/DynaPage.taf?file=/npp/journal/v28/n2/full/1300036a.html
> >
> >
> > Linkadge
>
>
>
> It looks like a negative feedback loop to me.
>
> Maybe increased 5-HT inhibitory outflow > reduced DA activation > reduced synaptic DA > upregulation of DAT and postsynaptic receptors = improved DA signal-to-noise ratio?
>
> Perhaps this helps to account for antidepressant discontinuation rebound improvement/mania.
>
> Just a thought.
>
>
> - Scott
poster:SLS
thread:623866
URL: http://www.dr-bob.org/babble/20060322/msgs/623908.html