Posted by tessellated on March 11, 2006, at 8:26:59
In reply to Re: Weird werid......, posted by sukarno on March 8, 2006, at 7:22:18
suk was probably about right.
i have a friend who's bipolar on depakote and it stabalized her.
i would bet that mania is a hyperdopaminergic state (particularly hers), and that the depakotes gaba reuptake inhibition isn't taking the same pathway as other gaba meds (benzo/opiate/barbs/alcho/xyrem/neurontin etc) which can enhance dopamine by blocking inhibition.i've found neurontin to also be rather libido enhancing i.e. dopaminergic like xyrem.
so it is probably a different pathway and/or brain circuit/anatomical structure that depakote enhances or inhibits.
but man: any heavy benzo use in my experience over time CONTRIBUTED massively to anxiety/agitation/depression. good meds-but only infrequently. and i think they were on a comparable level of withdrawl horror to amphetaimes.
poster:tessellated
thread:617133
URL: http://www.dr-bob.org/babble/20060310/msgs/618750.html