Posted by ed_uk on February 26, 2006, at 17:07:46
In reply to Re: provigil discussion, posted by mike99 on February 26, 2006, at 15:28:14
........modafinil, it's more relevent to amphetamines and methylphenidate.
Hi Mike
Losartan is, as you say, an angiotensin antagonist.
>it would not block peripheral NE alpha-1 receptors
That's right.
>I think only an alpha-1 antagonist such as prazosin or a mixed alpha/beta blocker such as labetalol or carvedilol could do this.
Among the alpha-1 antagonists, doxazosin (Cardura) is often used in favour of prazosin at the moment, at least it is in the UK. Doxazosin has a longer duration of action than prazosin and provides more consistent anti-hypertensive efficacy across the day. Doxazosin is usually administered once or twice daily, initially as a single dose at bedtime. It can be usefully combined with a beta blocker (such as atenolol or bisoprolol) if necessary. Alpha-1 antagonists do at times cause drowsiness and might theoretically reduce some of the effects of the stimulant. Doxazosin acts as a vasodilator, it reduces BP but not heart rate.
Regards
Ed
poster:ed_uk
thread:612884
URL: http://www.dr-bob.org/babble/20060219/msgs/613556.html