Posted by Larry Hoover on February 21, 2006, at 12:56:24
In reply to Question for SLS, posted by blueberry on February 20, 2006, at 19:37:23
> Your thoughts please Scott on some brain mechanistics? ...
>
> If I flood my brain with dopamine/norepinephrine neurotransmitters, from precursors, I get a pattern. First, I feel good for a couple hours, and then I start feeling more depressed than I had been. Also, I have tinnitus...but when my brain is flooded, that tinnitus quiets down dramatically to where I can hardly hear it. It's as if all the extra dopamine/norepinephrine floating around in there dampens everything down, slows down or shuts down release, puts receptors to rest, or something. Dunno. I wondered if you might know what mechanisms are at play here, so that when there is more than ample norepinephrine and dopamine floating around, it dramatically quiets tinnitus but also causes a worsening of depression. The same pattern holds true with serotonin precursors as well.I think you're describing the peripheral effects of dopamine on blood flow. Dopamine is given to treat shock, for example. It has opposing effects, though, at different concentrations, depending on whether or not there is substantial beta-adrenergic binding.
You're going to see greater perfusion with slight increases in serum dopamine. The correlation with tinnitus may indicate that you have poor circulation in your middle ear.
I'm just throwing ideas around. What do you think?
Lar
poster:Larry Hoover
thread:611554
URL: http://www.dr-bob.org/babble/20060219/msgs/611713.html