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Re: How come Wellbutrin and Risperdal don't cancel

Posted by linkadge on December 1, 2005, at 15:57:11

In reply to How come Wellbutrin and Risperdal don't cancel, posted by Deneb on December 1, 2005, at 14:26:13

Yes it is more complicated. The newer atypical antipschotics have a higher antagonist affinity for the serotonin receptors than they do for the dopamine receptors.

Risperdal blocks the serotonin 5-ht2a receptor much more potently then it does the d2 receptor.

As well, antipsychotics don't block all dopamine receptors, so if you take a dopamine enhancing drug, there still will be a net effect at certain dopamine receptors.

Another consideration is that Wellbutrin may have a stronger effect on noradrenaline than it does on dopamine.

Linkadge


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URL: http://www.dr-bob.org/babble/20051126/msgs/584252.html