Posted by linkadge on December 1, 2005, at 15:57:11
In reply to How come Wellbutrin and Risperdal don't cancel, posted by Deneb on December 1, 2005, at 14:26:13
Yes it is more complicated. The newer atypical antipschotics have a higher antagonist affinity for the serotonin receptors than they do for the dopamine receptors.
Risperdal blocks the serotonin 5-ht2a receptor much more potently then it does the d2 receptor.
As well, antipsychotics don't block all dopamine receptors, so if you take a dopamine enhancing drug, there still will be a net effect at certain dopamine receptors.
Another consideration is that Wellbutrin may have a stronger effect on noradrenaline than it does on dopamine.
Linkadge
poster:linkadge
thread:584242
URL: http://www.dr-bob.org/babble/20051126/msgs/584252.html