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maoi and ssri combination

Posted by davv on November 23, 2005, at 18:06:13

After many years on partially succesful treatment with high dose ssris I changed to phenelzine in desperation. about 60mg for one and a half year for ocd with excellent results especially when combined with at least 1mg of clonazepam. however i kept going seriously manic and high and i could not sleep. my partner threatened to leave. However i came off this cold and decided to start an ssir again. my depression within 2 weeks was back and my ocd was out of control again. I stopped the ssri after 12 weeks of not working 9a little early i know) and was desperate for phenelzine for relief. However the same has happened again and i know i cant spend the rest of my life on phenelzine. even though i know of the dangers, I cant go through that again. i have decided, and you may think it careless to initiate an ssri slowly and come off the phenelzine slowly without any approval. So I started at phen 3.625 tablets and 6mg of fluvoxamine as I was scared of interactions. (my intention is to come off phenelzine but i cant risk that serious dip. 5 days have past and i have gently uppe the fluvoxamine to 20mg through to today and have been slowly dropping the phenelzine and this is now 3 and a third of tablets. I feel fine in my body etc no symptoms of this serotonin syndrome.. does anyone think i could possibly have a fatal reaction on these dosages. my plan is to keep making micro changes over 4 months to both drugs so i end up on a thereupeuatic dose of fluvoxamine (about 350mg) and no phenelzine at all. call me stupid if you like but if i stop phenelzine for two whole weeks and wait possibly four months for an ssri to take effect then suicide could possibly result anyway. has anyone ever done this in this manner. and if anyone knows what dosages of an ssri and an maoi used together have been know to kill a man. If i keep dropping the phenelzine slowly etc i feel i would be ok. if i go even more slowly with the ssri.

PS please no criticism.


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poster:davv thread:581662
URL: http://www.dr-bob.org/babble/20051119/msgs/581662.html