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Re: alpha-2 agonists for cognitive clarity

Posted by sdb on October 28, 2005, at 18:38:05

In reply to alpha-2 agonists for cognitive clarity, posted by iforgotmypassword on October 28, 2005, at 13:03:37

praesynaptic alpha2-agonists e.g clonidine do have anesthesia, blood pressure lowering, sedating properties. It works mainly in Central nervous system in Locus coeruleus (pipmented ganglion cells with long axons), which regulates noradrenaline transmission. It reduces symphatotonicus and has influence on sleep, memory (discussed use for PTSD)

You can take it if you have performance anxiety combined with a betablocker. The weak sedation but especially the diminished noradrenaline transmission will definately not have good properties for cognitive clarity if you mean good effects for saving things in memory, think fastly, etc.

Clonidine will give strange dreams, weak sedation and dry mouth as side effects. After longterm use taper down slowly dosage.

Maybe it will "slow down" your brain thus can even have opposite good effects. It depends of your situation (nervousness, tensioned...)

There are also monoxidine and guanfacine with less sideeffects but I personally do not have experience.

~sdb


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