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Re: Triple reuptake inhibitor trial

Posted by SLS on October 20, 2005, at 21:47:09

In reply to Re: Triple reuptake inhibitor trial, posted by Mistermindmasta on October 20, 2005, at 20:18:21

Hi.

> Dopamine reuptake inhibition would definitely mean abuse potential, I shall assume. I wonder how that will come into play.

That might not necessarily be true. It might depend on which specific brain structures are affected. Nomifensine did not seem to have any abuse potential at all, and amineptine was at worst only of moderate risk. Still, I think you make a good point as to how the perception of abuse potential will affect a drug's approvability by regulatory agencies.

There are many important drugs that are used therapeutically by the ill that have the potential to be abused by the healthy. I don't find potential abusability to be a sufficient criterion to keep such drugs off the market. Cocaine still has valid uses as a topical anaesthetic for which a legal supply and distribution system exists.


- Scott

 

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