Posted by Chairman_MAO on September 8, 2005, at 23:43:18
In reply to Re: Does smoking affect core depressive symptomology ?, posted by willyee on September 8, 2005, at 18:54:11
Adding moclobemide to Parnate is pointless. Just increase the parnate does; it is a much more potent inhibitor of MAO-A than moclobemide. Adding phenelzine is a better idea; that is fully irreversible, as opposed to TCP which I believe has more of an amphetamine-like--save much more potent--reversible or semi-reversible inhibitory action. Thus, you'd knock out more MAO with phenelzine, leaving more TCP around to work--and get metabolized to sympathomimetic drugs.
Cigarette smoke contains harmala alkaloids as the MAO-A inhibitory principle. It also inhibits MAO-B, I believe (no time to read article now).
Nicotine also increases DA release via activation of nicotinic receptors on DA neurons. Of course, nicotine can have a dramatic positive effect on concentration. A nicotine patch works MUCH better for this purpose than a cigarette. Also, I found nicotine pataches help with phenelzine carb cravings. Unfortunately, they cause me sexual dysfunction because of the phenelzine (it seems that a squirrel twitching 4,000 miles away is enough to cause a sex problem with me now that I'm on this stuff).
poster:Chairman_MAO
thread:552302
URL: http://www.dr-bob.org/babble/20050901/msgs/552535.html