Posted by SLS on July 26, 2005, at 6:35:58
In reply to Re: If Klonopin caused you more depression..., posted by krybrahaha78 on July 26, 2005, at 1:52:27
> i have heard many times that klonopin also increases serotonin---so if this is that case, how can it cause depression?
I have read a few things that Klonopin reduces serotonin. There doesn't seem to be much consensus on this, I have seen both reported. There doesn't seem to be much interest in furthering research on Klonopin in this area.
- Scott
----------------------------------Neuropharmacology. 1995 Oct;34(10):1327-33. Related Articles, Links
Serotonin turnover rate, [3H]paroxetine binding sites, and 5-HT1A receptors in the hippocampus of rats subchronically treated with clonazepam.Lima L, Trejo E, Urbina M.
Laboratorio de Neuroquimica, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela.
Selective central benzodiazepine agonists, such as clonazepam, are known to modify serotonin and 5-hydroxyindoleacetic content in the brain. In order to further study the effect of this benzodiazepine on serotonin turnover rate, rats received clonazepam, 10 mg/kg for 10 days, and the concentrations of serotonin and 5-hydroxyindoleacetic acid were determined in the hippocampus after inhibition of monoamineoxidase with pargyline. The results indicate a reduction in the turnover rate of the monoamine. In addition, the systemic administration of clonazepam produced a decrease in the Bmax of [3H]DPAT binding to 5-HT1A sites in the hippocampus. By contrast, this effect was not observed if clonazepam was delivered into the dorsal raphe nucleus by osmotic minipumps. The binding of [3H]paroxetine to 5-HT reuptake sites was increased by the treatment with clonazepam. The present observations indicate that clonazepam produces a reduction of serotonin turnover rate in the hippocampus of the rat concomitant with a down-regulation of 5-HT1A binding sites, probably by an effect at the forebrain projections. There is also an up-regulation of the serotonin transporter, which might contribute to a reduction in the synaptic availability of serotonin during clonazepam treatment.
PMID: 8570030 [PubMed - indexed for MEDLINE]
- Scott
poster:SLS
thread:533405
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