Posted by Chairman_MAO on June 25, 2005, at 12:57:48
In reply to Calling Chairman_MAO » Nezirov, posted by ed_uk on June 24, 2005, at 20:56:38
Actually, cabergoline is not working as well in that department as it once did. There is a possibility, however, that the reason for this is that I started taking Nardil with bioperine, a bioavailability enhancer (to see if it would work better). I forgot the bioperine a few times in a row, and notice that I'm starting to feel the serotonergic-agent-withdrawal "brain zaps" every once and a while, so it most likely did increase plasma levels of it. Thus, it's possible that the increase was drastic enough that I was effectively taking too much for my body weight.
Also, opioids have an endocrinological effect (GnRH release inhibition) that also is detrimental to sexual functioning; that cabergoline would not address. Last weekend I found that if I took a LOT of it (6-8mg, I forget which) I was able to orgasm after an absurd amount of stimulation. I was astounded at how low a side effect profile cabergoline has, as with many other DA agonists there'd be a high probability that I'd get really nauseous, my sinuses would stuff up, I'd get really tired, hypotensive, etc. Instead I felt NO side effects.
As of now I am looking to add another agent to supplement the cabergoline, possibly something androgenic; I need to consult with my doctor. Another option is apomorphine, either by injection or sublingual tablet. That is a D1 and D2 agonist and very pro-sexual.
I also should add that if I weren't on 90mg of Nardil AND an opioid, the cabergoline might still be working. I will also talk to my doctor about slowly reducing the dosage of the Nardil perhaps to 75mg/day and the bupe to 8mg/day instead of 16 with the hope of things getting a lot better. That choice is DEAD LAST, as everything else besides the libido is great!
poster:Chairman_MAO
thread:518028
URL: http://www.dr-bob.org/babble/20050622/msgs/518687.html