Posted by Shawn. T. on June 21, 2005, at 15:16:47
In reply to Re: wellbutrin - 3rd leading cause of drug seizures ? » Shawn. T., posted by SLS on June 21, 2005, at 14:32:37
Bupropion inhibits the norepinephrine and dopamine transporters with low potency. A metabolite of bupropion, hydroxybupropion, contributes to the drug's effects as a norepinephrine and dopamine reuptake inhibitor. The (2S,3S)- isomer of hydroxybupropion is a much more potent norepinephrine reuptake inhibitor than bupropion. Other bupropion metabolites may also contribute to the drug's effects at the dopamine and norepinephrine transporters. Bupropion is a noncompetitive antagonist at nicotinic acetylcholine receptors including the alpha3beta2, alpha4beta2, alpha3beta4, and alpha4beta4 subtypes. Bupropion metabolites such as (2S,3S)-hydroxybupropion are also antagonists at nicotinic acetylcholine receptors. Most of this information was gleaned from Damaj et al. (2004).
Shawn
poster:Shawn. T.
thread:516244
URL: http://www.dr-bob.org/babble/20050617/msgs/516676.html