Posted by Minnie-Haha on May 16, 2005, at 12:16:36
In reply to Re: cymbalta and wellbutrin, posted by paul_d_234 on May 15, 2005, at 20:37:32
> According to others on this board, Wellbutrin prevents/slows down the break-down/metobolism of cymbalta. So if you add Wellbutrin to Cymbalta you need to a) Take them at different times during the day at least 8 hours apart b) try lowering the cymbalta some. The reason is that as the Wellbutrin prevents the cymbalta from being broken down/digested/metobolized then you have MORE cymbalta floating in your system causing more sedation/apathy/tiredness.
>
> Also you should take Wellbutrin SR or Wellbutrin but not Wellbutrin XL with Cymbalta.
>
> I mixed 100MG Wellbutrin in AM with 60MG Cymbalta at evening and its working very well for me (I was 90 MG Cymbalta but it was too much apathy/sedating/tiredness).I didn't know about the metabolism thing, but a similar strategy has been working for me. I take 200mg Wellbutrin SR in the morning (with my Trileptal 150mg -- I'm BP2), and then 40mg Cymbalta in the late afternoon (and another 300mg Trilep before bed).
It's taken a few months to get everything all worked out, but I'm feeling pretty dang good.
poster:Minnie-Haha
thread:498067
URL: http://www.dr-bob.org/babble/20050516/msgs/498489.html