Posted by Shawn. T. on May 11, 2005, at 1:09:13
In reply to Benzo Dopamine, posted by willyee on May 10, 2005, at 21:53:53
Klonopin decreases dopamine release in regions of the striatum such as the caudate nucleus due to its inhibition of dopamine neurons in the substantia nigra. It may also decrease dopamine turnover in some regions of the cortex. I was unable to find any information about the effects of Klonopin on dopamine levels in the nucleus accumbens. Valium and other benzodiazepines have been shown to decrease dopamine in this region, so I would assume that Klonopin does as well. The benzodiazepines represent a counterexample to the suggestion that all potentially addictive drugs increase dopamine levels in regions such as the nucleus accumbens.
Shawn
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=6152348
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=207628
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7616453
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9181633
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1362661
poster:Shawn. T.
thread:496246
URL: http://www.dr-bob.org/babble/20050510/msgs/496280.html