Posted by Ritch on May 3, 2005, at 22:24:12
In reply to Re: Keppra - causes mania? » Ritch, posted by theo on May 3, 2005, at 11:59:56
> > > Has anyone had a manic reaction to Keppra?
> > >
> > > Thanks.
> > >
> > >
> > > - Scott
> >
> > I noticed some irritability associated with using it. But it seems to be dose related and the irritability wasn't accompanied by increased psychomotor agitation and angry rumination. The "irritability" was more to do with increased assertiveness and a disinhibiting effect accompanied by being more aware of what's going on. Difficult to describe, but it seemed to work on my ADHD symptoms, especially short term working memory. Improved working memory makes it a little easier to become irritable in my case.
>
> At what dose and what dosing schedule were/are you taking Keppra?
>
>Theo, I started out with 250mg twice daily a couple of years ago (tried for several months with Depakote and low-dose Effexor and clonazepam). It seemed to make me irritable and that is why I stopped it. I restarted it at 125mg twice daily recently (after having been off all AD's, just Depakote and clonazepam now). I noticed an uptick of irritability again. But.. I don't notice an *explosive* irritability I had while on AD's, just an assertive grouchiness-readiness to complain and squawk, stuff like that. I've read your posts about dosing schedules.... I'm thinking of splitting into 125mg TID to see how that goes.
poster:Ritch
thread:487624
URL: http://www.dr-bob.org/babble/20050428/msgs/493398.html