Posted by Chairman_MAO on May 2, 2005, at 10:17:08
In reply to Re: Strattera » Chairman_MAO, posted by zeugma on April 28, 2005, at 18:11:35
I do consider the TCAs way closer in effect than SSRIs to what an antidepressant should be, but they still are not there. An antidepressant should induce a euthymic zest for life, a more-or-less indefatigable sense of genuine well-being. True remission from dysthymia for me felt like being born again, or waking up from a 24-year nightmare. If you take an MAOI and it works, you will know what I'm talking about. If I had to choose an AD besides an MAOI to take (well, one from the US market), it would be desipramine. That definitely put a smile on my face at times, while no SSRI ever did, that's for sure.
NO drug intended for people with psychiatric disorders should have ANY kappa agonist activity; it can do nothing except cause some dysphoria at BEST, and induce psychosis at worst. Buprenorphine, which is known among the opioids for being an extraordinarily effective antidepressant, is a kappa antagonist.
poster:Chairman_MAO
thread:491037
URL: http://www.dr-bob.org/babble/20050428/msgs/492624.html