Cymbalta has weak effects on dopamine... » jessers11581

Posted by cache-monkey on April 21, 2005, at 12:03:00

In reply to another Cymbalta question, posted by jessers11581 on April 20, 2005, at 19:56:08

According to a couple of studies done on rats, Cymbalta (duloxetine) showed increases in dopamine but these were much weaker than the effect on norepinephrine and somewhat weaker than its effects on serotonin.
[ http://www.biopsychiatry.com/alp2ant.htm
and http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9048781&dopt=Abstract ]
I'd think that at its therapeutic dose the norepinephrine increase would be dominant, the serotonin increase secondary, and the dopamine increase negligible.
HTH,
cache-monkey
> Does Cymbalta only affect serotonin and norepinephrine, or does it increase dopamine as well? If so, maybe I don't need to add Wellbutrin...

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another Cymbalta question jessers11581 4/20/05
Re: another Cymbalta question » jessers11581 Phillipa 4/20/05
It doesn't affect dopamine... » jessers11581 Colleen D. 4/21/05
Re: It doesn't affect dopamine... alienatari 4/21/05
Cymbalta has weak effects on dopamine... » jessers11581 cache-monkey 4/21/05

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