Posted by SLS on March 3, 2005, at 12:46:20
In reply to Paging SLS, posted by olysi79 on March 2, 2005, at 19:04:43
> Scott, you have always had good info, do you have any insight on this?
>
> > Any answers on this? Does it have anything to do with the NE re-uptake or the Dopamine re-uptake or neither?I have not really researched Wellbutrin in quite awhile.
Wellbutrin is probably the least understood of all antidepressants - not that any of them are really understood. There have been entire symposia dedicated to Wellbutrin without very much agreed upon. I am very dubious that its DA reuptake inhibition is significant enough to be relevant. The same would be true of its active metabolites. I am also dubious that any NE reuptake is going on, despite more recent literature indicating otherwise. However, there seems to be at least some consensus that bupropion does increase activity in noradrenergic pathways.
> It's ironic that I can handle takign a stimulant like adderall but not wellbutrin.
This is where I have problems with the NE and DA reuptake stuff regarding Wellbutrin. Adderall works by blocking the DA and NE transporters and causes the release of those neurotransmitters as well. I believe Wellbutrin treats you differently because it acts differently. The "old" way of thinking of Wellbutin is that it only weakly inhibits the reuptake of DA, and that this is not likely to account for its antidepressant effect. It does not inhibit the reptake of NE. Nonetheless, it exerts a noradrenergic effect by unknown mechanisms. It could therefore be anxiogenic without being stimulating.
> Also, I think it might have caused soem urinary hesitation issues with my Paxil and Trazodone. Wierd.
Both of these drugs have significant anticholinergic properties. That probably accounts for the side effect you experience.
I guess I should do more research on Wellbutrin. My information is way out of date!
- Scott
poster:SLS
thread:465398
URL: http://www.dr-bob.org/babble/20050227/msgs/465962.html