Posted by SLS on February 5, 2005, at 6:13:00
In reply to Re: ABILIFY may have trashed my LIBIDO » SLS, posted by zeugma on February 4, 2005, at 19:10:33
Hi Z.
> > The other thing I was thinking is that it might produce a pro-serotonin effect like the SSRIs by acting to stimulate 5-HT1a receptors, but I really haven't thought the whole thing through yet.
> hi Scott. And I apologize for 'tossing your name around' before,
:-)Don't be silly! I was extremely happy and flattered that you did!
> Buspirone stimulates 5-HT1A receptors and yet it can reverse SSRI s/e,One of the things that must be considered is which 5-HT1a receptors are being stimulated and in which brain circuits these neurons operate. Some receptors act at inhibitory autoreceptors and exist both presynaptically and at somatodendritic cites. Others receptors are stimulatory at postsynaptic cites. I could be wrong, but I think Abilify has a much higher affinity to these receptors than has buspirone.
-> I'm just playing devil's advocate. The net effect could be inhibitory upon serotonergic neurons as you describe. I hope you are right. Abilify seems to be helpful to me, and I would rather not have a reason to do without it. I am going to try, though, as an experiment. I'd like to see what happens to my libido and mood. I'll let you know.
On another note, I saw my doctor yesterday. He "allowed" me to go up to 70mg of Parnate. I had wanted to go up to 80mg. I know that it represents a dead-end for me, but I was hoping to squeeze a little more out of my current treatment. I'm simply using it as a bridge until something new comes along. I might have to pull some teeth, but I might pursuade him to let me go to 120mg if I can get him to talk to my old doctor. Unfortunately, my current doctor had a bad experience with the only patient he tried high-dosage Parnate therapy on. At 120mg, this patient reported having a crushing headache. He was sure that it was NOT a spontaneous hypertensive event, but still, he is extremely reluctant to see it happen again.
Thanks, Zeugma. I always appreciate your help and sharp mind.
- Scott
poster:SLS
thread:452986
URL: http://www.dr-bob.org/babble/20050202/msgs/453537.html