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Re: A RIMA as effective as an MAOI? » johnnystats

Posted by SLS on January 17, 2005, at 14:19:44

In reply to A RIMA as effective as an MAOI?, posted by johnnystats on January 16, 2005, at 9:53:13

> While i agree that nardil is currently the best med out there for anxiety disorders and depression, many pdoc's still won't prescribe it because of the dietary restrictions(they might get sued). I wonder if anyone knows if the drug companies are working on a RIMA that actually works as well as nardil. Because until that happens, many people on this board are going to be bombarded with med combinations before the pdoc finally prescribes nardil.

The only RIMA that I know is currently available (excluding the US) is moclobemide. For most people with severe depression or social anxiety/phobia, moclobemide is not nearly as effective as Nardil or Parnate. It is quite possible that irreversiblity confers greater efficacy. Brofaromine is a RIMA that was available in Europe briefly. I have no idea why it was discontinued. Oops. I forgot about toloxatone. I think this RIMA is still available in France. I haven't heard anything about it to form an opinion. Befloxatone is another RIMA that was studied closely, but was never approved anywhere that I am aware of.

I guess you could try moclobemide. Many people feel something positive during the first week of treatment. Unfortunately, it has a habit of pooping-out quickly, with escalating dosages necessary to recapture the effect. Many people go as high as 1200mg. If you are a partial responder to moclobemide, perhaps that would act as an incentive for your doctor to agree to try Nardil or Parnate.

Good luck.


- Scott

 

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