Posted by ed_uk on December 28, 2004, at 10:39:24
In reply to Re: Experience w/GABITRIL...any longtime users?, posted by jeopardy on December 26, 2004, at 10:01:34
Low-dose tiagabine effectiveness in anxiety disorders.
Schaller JL, Thomas J, Rawlings D.
Professional Medical Services of Naples, Naples, Florida, USA.
BACKGROUND: Gamma-aminobutyric acid (GABA), the predominant inhibitory neurotransmitter of the central nervous system, is involved in the pathophysiology of a wide variety of disorders, including anxiety. Tiagabine hydrochloride acts as a selective GABA reuptake inhibitor (SGRI). METHODS AND RESULTS: Consecutive patients were offered tiagabine in 1-mg incremental doses for the treatment of anxiety, primarily generalized anxiety disorder. Individuals failing anxiety treatment with benzodiazepines, selective serotonin reuptake inhibitors, and buspirone, and/or with a strong family or personal history of substance abuse were allowed trials. The SGRI tiagabine improved anxiety and was well tolerated by adult patients with generalized anxiety disorder as well as one patient with anxiety secondary to acute antidepressant withdrawal. One disinhibition treatment failure is also discussed. CONCLUSION: In acute anxiety treatment, very low initial dosing with gradual increases may be sufficient for anxiety effects, when compared with the higher doses of tiagabine used in epilepsy treatment. Tiagabine may be useful in the treatment of generalized anxiety disorder.
poster:ed_uk
thread:434020
URL: http://www.dr-bob.org/babble/20041228/msgs/434983.html