Posted by linkadge on December 17, 2004, at 17:18:27
In reply to Re: Elzasonan: An alleged antidepressant, posted by ravenstorm on December 16, 2004, at 21:15:29
We have a few such autoreceptor antagonists already. Lithium is a serotonin autoreceptor antagonists, as is pindolol, and trazedone.
There is another problem, pindolol can make people very agressive when added to a SSRI. I think that blocking the autoreceptors and using an SSRI is asking for trouble. What if, indeed the level of serotonin was too high? The brain would have very little way to shut it down.
Another thing to note is that the post synaptic receptors have to downregulate as well for the drug to be effective. The postsynaptic 2a receptors need to downregulate too for the drug to be effective. This will take time.
Remember too that blocking the neurogenesis process blocks the AD effect of most popular antidepressants. Depression doesn't happen over night, and likewise I don't think it can be sucessfully *cured* over night as well.
Linkadge
poster:linkadge
thread:430269
URL: http://www.dr-bob.org/babble/20041217/msgs/430972.html