Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Elzasonan: An alleged antidepressant

Posted by linkadge on December 17, 2004, at 17:18:27

In reply to Re: Elzasonan: An alleged antidepressant, posted by ravenstorm on December 16, 2004, at 21:15:29

We have a few such autoreceptor antagonists already. Lithium is a serotonin autoreceptor antagonists, as is pindolol, and trazedone.

There is another problem, pindolol can make people very agressive when added to a SSRI. I think that blocking the autoreceptors and using an SSRI is asking for trouble. What if, indeed the level of serotonin was too high? The brain would have very little way to shut it down.

Another thing to note is that the post synaptic receptors have to downregulate as well for the drug to be effective. The postsynaptic 2a receptors need to downregulate too for the drug to be effective. This will take time.

Remember too that blocking the neurogenesis process blocks the AD effect of most popular antidepressants. Depression doesn't happen over night, and likewise I don't think it can be sucessfully *cured* over night as well.


Linkadge


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:linkadge thread:430269
URL: http://www.dr-bob.org/babble/20041217/msgs/430972.html