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more on metabolism, side effects (chemist?)

Posted by Franz on December 15, 2004, at 15:25:17

In reply to Tianeptine - thanks all......................., posted by jasmineneroli on December 14, 2004, at 22:07:27

Hello,

All the articles I read show very mild side effects (if any) and discontinuation problems for tianeptine.

Some caught my attention, but I do not have the knowledge to completely understand the clinical significance.

e.g.

Tianeptine, a new tricyclic antidepressant metabolized by beta-oxidation of its heptanoic side chain, inhibits the mitochondrial oxidation of medium and short chain fatty acids in mice.

Fromenty B, Freneaux E, Labbe G, Deschamps D, Larrey D, Letteron P, Pessayre D.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&list_uids=2597170&dopt=Citation

I do not know if this inhibition take splace in humans at therapeutic doses and if this is too bad or what.

Anyone can help?.

Thanks

p.s. if someone was taking 240 tablets daily and survived, that is good!

 

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poster:Franz thread:427416
URL: http://www.dr-bob.org/babble/20041211/msgs/429988.html