Posted by Dave001 on November 22, 2004, at 16:12:42
In reply to Down-Regulation and Tolerance: Question, posted by whitdaddy on November 3, 2004, at 9:14:45
> I have been fighting treatment resistant depression for 14 years and have experienced tolerance and "poop-out" with every single medication that I have tried.
>
> I have been told that I am part of a rare percentage of the population that has a highly sensitive neuro-protective system. What I amI think "highly efficient nervous system" might be a better way of saying the same thing; but that's just me...
> wondering is what biological actions are responsible for this. Does it have something to do with my liver producing enzymes to eliminate what it perceives as a threat? Is it simply the neurons in my brain adjusting levels of receptor and/or reuptake sites?The precise mechanisms are complicated and no doubt variable depending upon the drug. It is doubtful that liver enzyme induction is the problem, though, since this is much easier to measure and doesn't seem to happen much with most drugs we use in depression and related conditions.
> Whatever you think the problem might be, is there anything I can do to "trick" my body into accepting medications? Any and all information by anyone is much appreciated.
>Maybe. Who knows? The most obvious approach would be to try cycling between different medications. When a given medication or combination stops working, switch to another which has worked for you in the past.
poster:Dave001
thread:30864
URL: http://www.dr-bob.org/babble/20041118/msgs/419041.html