Posted by Willyee on November 8, 2004, at 15:25:04
In reply to The Forbidden Combination, posted by ed_uk on November 8, 2004, at 10:13:02
> Hello everyone...
> Perhaps the most feared drug interaction in all of psychopharmacology is that which may occur when an SSRI is combined with an MAOI. The potentially fatal Serotonin Syndrome appears to be a frequent outcome.
>
> It is clear from the literature, however, that not all patients treated with this combination develop serious side effects. It is even possible that some people may benefit from this hazardous form of treatment.
>
> I would be very interested to hear from anyone who has taken a serotonin reuptake inhibitor (eg. an SSRI, venlafaxine, clomipramine, imipramine) at the same time as an MAOI such as Nardil or Parnate.
>
> Why did you take this combination?
> -treatment resistant depression
> -OCD
> -An uncontrolled anxiety disorder etc.
>
> What were the effects of this combination?
> -serotonin syndrome
> -therapeutic benefit
> -seizures
>
> The incidence of the Serotonin Syndrome seems to be much lower with moclobemide+SRI than it is with a classical MAOI+SRI. Has anyone ever been treated with this combination?
>
> Thank you for reading my post...
>
> All the best,
> Ed.>
I am a poster child for challenenging the Moais no-no list.I am not bragging about this,i just came to the conclusion that the docs themselves came damn near close to hospitilizing me,with little concern of interaction,so whats the difference.I also decedided living with the feelings,just isnt living,and i accepted the dangers if it meant possably getting better,so i have experminted with parnate over the past 4 years.
I have tried it with numerous things,from kava kava,to ghb,to most of your common sedatives,to certain nutrients,caffeine,beta blocker benzos etc.
From all this,i will tell you,the one thing that truly was harmful,was adding it to an ssri,or imiprimine the tca,they actualy did their home work on that,and if i can only go by my exper,i will say DO NOT TAKE A MAOI WITH another ssri or tca anti-depressant.
What it did was put my brain in a lock,i had small seizures in my legs,constant twitching,i also had a very scary hugh where you talk a lot,but you know you are making yourself noticable and talking nonsense,worst off it will make it impossable to sleep,you have to wait the interaction out,theres no way around it,forget adding a benzo to help this will add to the situation and worsen it,there is also when it ends a rebound depression,one i can only imagine is like the one described the day after x or other hard street drug.
I would not do it again,i have tossed every ssri,and other anti depressant away.Now i am not advocating expierments,but the one surprising thing i was able to combine was parnate,and liquid deprenyl.Parnate seems most active the 30-60 min of its ingestion,so when i took liq depr at different times in the day,at small doses it did not seem to have any side effects,and i went through an entire bottle over time of this.
Vivarin too,has worked well in combo with parnate.My goal is too keep the monster at bay,one pill will not do this for me,so i have bult a small aresnal,this however took time and painstaking trial and error,and of course its not done yet,and at and direction the industry is moving,prob wont be in my lifetime,at least the substances i have discovered for myself now allow me to function,i.e go to work,date,workout,watch tv,and i have more good days than bad.
I wish i had the option of a single pill,or two that consistently helped,that is what i search for,for now i listen to my body,and try to take what i feel it needs at the moment.
Note: I think its responsable to note i spent tons of research on parnate before deceding to start augmenting it.It is not a medication to take lightly.
>
poster:Willyee
thread:413243
URL: http://www.dr-bob.org/babble/20041108/msgs/413375.html