Posted by jboud24 on October 31, 2004, at 18:59:51
In reply to Re: Tricyclic ADs vs. SSRIs » jboud24, posted by jujube on October 31, 2004, at 18:01:20
TCA's are probably better than SSRI's for anhedonic depression due to their effects on norepinephrine reuptake inhibition. Desipramine has the strogest and most selective profile in regards to the NRI effects. Clomipramine possesses them as well, but it is more of a dual reuptake inhibitor.
Perhaps combining a selective SSRI like Zoloft or Celexa with a selective NRI TCA like desipramine would be something to look into. You would probably risk less hypotension and dizziness with such a combination.
Good luck with your doc, my next appointment is Tuesday with a new pdoc. I'll be asking for a trial of Nardil and Klonopin. I'm tired of the monoamine reuptake inhibitors, they dont seem to be cutting the proverbial mustard for me.
Justin
poster:jboud24
thread:409651
URL: http://www.dr-bob.org/babble/20041029/msgs/409751.html