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Re: Moclobemide hope? » ravenstorm

Posted by King Vultan on October 5, 2004, at 23:12:09

In reply to Re: Moclobemide hope?, posted by ravenstorm on October 5, 2004, at 17:22:37

> Then why is the dosage instruction to take twice a day?


According to data in "Clinical Advances in Monoamine Oxidase Inhibitor Therapies", the half life of disappearance of MAO-A inhibition in the brain is 6 hours for moclobemide. The half life of the drug itself is listed as 1-3 hours. With half lives that short, I think you would want to take it twice a day to maintain more of a constant effect.

Todd

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poster:King Vultan thread:399047
URL: http://www.dr-bob.org/babble/20041002/msgs/399448.html