Posted by jparsell82` on September 16, 2004, at 19:51:15
Has anyone had any experience with Requip? It being a D2/D3 agonist(with higher affinity for D3 than D2) and also having moderate affinity for opioid receptors, I would think it would be a good choice for social anxiety and depression. I know some people have posted here before about the similar Mirapex, but Mirapex doesn't have the additional opioid effect although it's probably more potent than Requip in regards to D2/D3 receptors. I think I read on here before the problem with Mirapex is it worked at first for Social Phobia and then eventually pooped out... possibly because of receptors being desensitized. I'm also taking Effexor and Klonopin. One study I read on Effexor said it increases the responsiveness of the dopaminergic(mainly D3) systems.... so perhaps the Effexor would potentiate the Requip and/or prevent receptor desensitization. Anyways, this is all a bunch of rambling but I was curious to see if anyone had any comments.
poster:jparsell82`
thread:391712
URL: http://www.dr-bob.org/babble/20040915/msgs/391712.html