Posted by linkadge on August 29, 2004, at 18:05:54
In reply to Re: A possible explaination. » owensmar, posted by Maximus on August 29, 2004, at 17:35:38
"I can partially answer to you. Pramipexole (Mirapex) is a D3 receptor agonist. It has been proven effective in treatment-resistant depression. However it has also some drawbacks. Anger, rage and hyperactivity have also been reported as side effects."
Mirapex also activates the D2 receptor a little less potently than the D3. This *may* be more responsible for those side effects than the d3 receptor activation.
Personally I think a golden antidepressant combo would be this. Buspar and mirapex. Buspar would be the serotonin agonist at the 5-ht1a receptor and provide antidepressant activity here, as well, mirapex would hit the d3 receptors. As a bonus, the buspars d2 antagonism would block some of the mirapex's d2 receptor agonism, and perhaps some of these side effects.
Linkadge
poster:linkadge
thread:383680
URL: http://www.dr-bob.org/babble/20040825/msgs/383796.html