Posted by Kon on August 20, 2004, at 22:37:26
In reply to kp.-benzo least likely to cause cogn. impair.?, posted by alesta on August 20, 2004, at 14:59:27
> i found an anecdote where someone states that klonopin is the only benzo that hasn't affected her memory or cognition. any thoughts?
This is somewhat consistent with what I've come across in the literature. Chouinard (2004)writes,"The relative solubility of benzodiazepines contributes to memory impairment. The greater the lipid solubility, the greater the likelihood of memory damage...clonazepam has low lipid solubility and is least likely to cause memory impairment."
The lipid solubility (i.e. HPLC retention index (relative to diazepam)given in that paper are:
Diazepam-1.0
Xanax-0.54
Lorazepam-0.48
Clonazepam 0.28If this is accurate and all other things being relatively equal (?), clonazepam would seem to be one of the better benzos wrt memory while diazepam one of the worse.
See: J Clin Psychiatry 2004;65 (Suppl 5):7-12.
poster:Kon
thread:380009
URL: http://www.dr-bob.org/babble/20040817/msgs/380188.html