Posted by Larry Hoover on August 17, 2004, at 13:33:41
In reply to Re: How do you know if a volunteer is healthy?, posted by SLS on August 16, 2004, at 15:17:03
> I don't think it is necessarily the point to prove that these drugs precipitate a suicidal state in an otherwise healthy individual. They might never do that. It might be that this happens only in those people who have a biological vulnerability for depression or perhaps only in those people whom express the depressive phenotype. In other words, the inability to get this thing to happen in a healthy volunteer doesn't preclude its happening in unhealthy individuals. Personally, I have been quite vocal in my belief that Prozac and other antidepressants produce suicidal states independent of any clinical antidepressant effect. I also don't believe that the appearance of akathisia is requisite for this to happen. Reboxetine, a selective NE reuptake inhibitor, made me suicidal in the absence of akathisia, but in the presence of anxiety, which Prozac and other SSRIs are well known to cause.
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> - ScottYa, it could be entirely about liver enzyme isoforms, induction, and inhibition.
Lar
poster:Larry Hoover
thread:208072
URL: http://www.dr-bob.org/babble/20040817/msgs/378750.html