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Re: Tricyclics+Amphetamines

Posted by Philidor on July 13, 2004, at 15:11:34

In reply to Re: Tricyclics+Amphetamines » anxiety_free, posted by Sad Panda on July 4, 2004, at 11:04:22

Ok, but I'm just struck by the language of that PI.
"STRIKING AND SUSTAINED INCREASES in the concentration of d-amphetamine in the brain;"

I mean, this sounds like it should be major news... that a little (or more than a little) nortryptiline or some other TCI could have such a dramatic effect in boosting response to amphetamine. Yeah I know SSRIs and others are sometimes used to help amphetamine treatment, but STRIKING AND SUSTAINED INCREASEs?? I mean, this should be more than just a "by the way" comment. I just don't get it. It sounds like they're saying Tricyclics have a huge augmenting effect on amphetamines! It should be BIG NEWS, should it not?

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poster:Philidor thread:362828
URL: http://www.dr-bob.org/babble/20040712/msgs/365718.html